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Still's Disease & Autoinflammatory Digest: August 2022 |
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StillsNow is an educational resource for physicians and patients, dedicated to Still’s Disease, Autoinflammatory and Febrile disorders. Be sure to subscribe to our monthly StillsNow Podcast on Apple or Android podcast platforms. |
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Genetic Testing for Autoinflammatory DiseaseNot all patients with periodic fevers fit neatly into diagnostic categories. Some can be diagnosed as Still’s disease (based on criteria) while others can be classified as autoinflammatory diseases (AID) and some may be unclassifiable, clinically or genetically. AID is defined as illnesses caused by primary dysfunction of the innate immune system. Many of these… |
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Disease Activity Scoring in Adult-onset Still's diseaseStill’s disease in adults (AOSD) or children (sJIA) can have dramatic symptom severity, making it easy to gauge disease activity and response to therapy, especially at the outset. However, a validated measure of disease activity has not been agreed (for clinical trial and treatment assessments). A new study compares two such activity measuresin a large… |
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JAK Inhibitors in Difficult Still’s DiseaseA small retrospective study suggests that patients with difficult to treat adult-onset Still’s disease (AOSD) or sytemic juvenile idiopathic arthritis (sJIA) may respond well to JAK inhibitor (JAKi) agents – presumable by blocking pro-inflammatory cytokines, notably IL-6 and IFN. Patients with sJIA or AOSD were gathered based on a national survey conducted in the departments of rheumatology,… |
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