CARD8 SNP rs11672725 (OR 3) may be a Genetic Variant for AdultStill’s Disease. AOSD has unregulated NLR3 inflammasome activity. Study of 66 AOSD & 128 controls, showed AOSD to have low CARD8, higher caspase-1, IL-1β and IL-18; more systemic Sxs https://t.co/rpypR4cLfM
StillsNow
An educational site for Physicians and Patients with Still's disease (systemic juvenile idiopathic arthritis), periodic fever syndromes and autoinflammatory diseases
